Gajera, Nilesh N. published the artcileSynthesis, characterization and biological screening of new spirochromanones, Safety of 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, the main research area is spirochromanone leucine benzenesulfonamide preparation antibacterial antifungal.
New spirochromanones I (R = substituted phenyl) based on N-[1-(6-bromo-4-oxo-3,4-dihydro-1’H-spiro[chromene-2,4′-piperidin]-1′-yl)-3-methyl-1-oxobutan-2-yl]benzenesulfonamides were synthesized by series of reactions, such as cyclization, deprotection, coupling, and condensation. The compounds were tested for their activity against fungi and pathogenic strains of bacteria. The compounds bearing F, cyano, and OCF3 groups at para position showed competitive antifungal activity, while the compounds carrying either a halo or Me substituent at ortho position showed significant antibacterial activity.
Journal of Chemical and Pharmaceutical Research published new progress about Antibacterial agents. 7079-48-3 belongs to class chlorides-buliding-blocks, name is 4-Fluoro-2-methylbenzene-1-sulfonyl chloride, and the molecular formula is C7H6ClFO2S, Safety of 4-Fluoro-2-methylbenzene-1-sulfonyl chloride.
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