On September 11, 2014, Beesu, Mallesh; Malladi, Subbalakshmi S.; Fox, Lauren M.; Jones, Cassandra D.; Dixit, Anshuman; David, Sunil A. published an article.Quality Control of 2-Chloro-4-methyl-1-nitrobenzene The title of the article was Human Toll-Like Receptor 8-Selective Agonistic Activities in 1-Alkyl-1H-benzimidazol-2-amines. And the article contained the following:
Toll-like receptor (TLR)-8 agonists strongly induce the production of T helper 1-polarizing cytokines and may therefore serve as promising candidate vaccine adjuvants, especially for the very young and the elderly. Earlier structure-based ligand design led to the identification of 3-pentyl-quinoline-2-amine as a novel, human TLR8-specific agonist. Comprehensive structure-activity relationships in ring-contracted 1-alkyl-1H-benzimidazol-2-amines were undertaken, and the best-in-class compound, 4-methyl-1-pentyl-1H-benzo[d]imidazol-2-amine, was found to be a pure TLR8 agonist, evoking strong proinflammatory cytokine and Type II interferon responses in human PBMCs, with no attendant CD69 upregulation in natural lymphocytic subsets. The 1-alkyl-1H-benzimidazol-2-amines represent a novel, alternate chemotype with pure TLR8-agonistic activities and will likely prove useful not only in understanding TLR8 signaling but also perhaps as a candidate vaccine adjuvant. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Quality Control of 2-Chloro-4-methyl-1-nitrobenzene
The Article related to alkyl benzimidazol amine derivative preparation toll receptor 8 adjuvant, Pharmacology: Structure-Activity and other aspects.Quality Control of 2-Chloro-4-methyl-1-nitrobenzene
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