On December 3, 2021, Zou, Ying; Huang, Zhi-Cheng; Xiang, Min; Li, Chen-Yi; Li, Xia; Tian, Fang; Wang, Li-Xin published an article.SDS of cas: 14602-86-9 The title of the article was Spiro-Scaffold Chiral Organocatalyst of 3,2′-Pyrrolidinyl Spiro-oxindole Amine and its Catalytic Evaluation in the Enantioselective Aldol Condensation between 3-(3-hydroxy-1H-pyrazol-1-yl)-Oxindole and Paraformaldehyde. And the article contained the following:
Spirocyclic chiral organocatalyst based on (R)-spiro[indoline-3,2′-pyrrolidine]-2-one was successfully prepared from racemic 1,2-dihydrospiro[indole-3,2′-pyrrolidine]-2-one using L-menthol as chiral auxiliary in 4 steps in 28%-40% overall yield with at least 99% ee in scale up preparation and its catalytic activity was evaluated in the enantioselective aldol condensation between 3-(3-hydroxy-1H-pyrazol-1-yl)oxindoles I (R1 = H, 5-Me, 5-MeO, 5-Cl, 7-Me; R2 = Me, H2C:CHCH2, n-Bu, Ph, PhCH2, 4-BrC6H4CH2) and paraformaldehyde. The spiro organocatalyst showed superior catalytic activity and selectivity compared with its counterparts, and most substrates offered good to excellent results with up to 96% yield and 96% ee. The experimental process involved the reaction of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl carbonochloridate(cas: 14602-86-9).SDS of cas: 14602-86-9
The Article related to oxindole hydroxymethyl hydroxypyrazolyl asym synthesis, hydroxypyrazolyl oxindole enantioselective aldol condensation paraformaldehyde spiro pyrrolidine organocatalyst, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.SDS of cas: 14602-86-9
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics