On January 28, 2022, Zhang, Yong; Lai, Guowei; Nie, Longjun; Lu, Dongliang; Fan, Xiaolin published a patent.Application In Synthesis of 2-Chloro-4-methyl-1-nitrobenzene The title of the patent was Difluorobenzyl reagent, its preparation method and application. And the patent contained the following:
The difluorobenzyl reagent has chem. structural formula I or II shown in claim 1, wherein R is R1 substituted Ph, etc.; R1 is H, etc.; Ar is R2 substituted 4-nitrobenzyl, etc.; R2 is H, etc. The difluorobenzyl reagent is 2-(2,4-dinitrophenyl)-2,2-difluoro-1-phenylethanone, etc. The preparation method includes performing first nucleophilic addition of 2,4-dinitrotoluene and aldehyde under condition of first catalyst (1,8-diazabicyclo[5.4.0]undec-7-ene, etc.) to obtain first nucleophilic structure, reacting with first oxidant (2-iodoxybenzoic acid, etc.) to obtain first oxidation structure, mixing with first selective fluorine reagent (1-chloromethyl-4-fluoro-1,4-diazabicyclo[2,2,2]octane bis(tetrafluoroborate) salt) and first additive (potassium phosphate, etc.), and performing first fluorination to obtain compound I. The preparation method further includes performing second nucleophilic addition reaction of nitro-substituted toluene and benzaldehyde under condition of second additive (1,8-diazabicyclo[5.4.0]undec-7-ene, etc.) to obtain second nucleophilic structure, reacting with second oxidant (2-iodoxybenzoic acid, etc.) to obtain second oxidation structure, mixing with second selective fluorine reagent (1-chloromethyl-4-fluoro-1,4-diazabicyclo[2,2,2]octane bis(tetrafluoroborate) salt) and third additive (potassium phosphate, etc.), and performing second fluorination to obtain compound II. The invention has potential medicinal value. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Application In Synthesis of 2-Chloro-4-methyl-1-nitrobenzene
The Article related to difluorobenzyl preparation application, Aliphatic Compounds: Nitro and Nitroso Compounds and other aspects.Application In Synthesis of 2-Chloro-4-methyl-1-nitrobenzene
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics