Yang, Ke; Zhang, Xiong; Yang, Fang; Wu, Fengshou; Zhang, Xiulan; Wang, Kai published an article in 2017, the title of the article was DNA photocleavage and binding modes of methylene violet 3RAX and its derivatives: Effect of functional groups.Safety of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride And the article contains the following content:
With 4′-amino-N,N-diethylaniline and aniline as starting materials, methylene violet 3RAX 1 and its derivatives 2-5 were synthesized. The 5 compounds were characterized by IR, UV-visible, and 1H NMR spectroscopy and mass spectrometry. The binding mode between the synthesized compounds and DNA were investigated. The results showed that both compounds 1 and 5 bound to DNA by an intercalative mode, while compounds 2-4 interacted with DNA through a mixed binding mode involving groove binding and electrostatic interactions. The photocleavage ability of the 5 compounds to DNA were calculated to be 38, 40, 30, 20, and 13%, resp., when their concentration was adjusted to 400 μM. The singlet oxygen production of compounds measured by the 1,3-diphenylisobenzofuran method was consistent with the trend of DNA photocleavage ability. The DNA studies suggested that the binding mode between methylene violet 3RAX and DNA, the ability of methylene violet 3RAX to generate singlet oxygen, and the DNA photocleavage activity could be adjusted through modification of the amino group on methylene violet 3RAX. The experimental process involved the reaction of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride(cas: 4569-86-2).Safety of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride
The Article related to dna photocleavage methylene violet derivative preparation binding photodynamic therapy, General Biochemistry: Nucleic Acids and Their Constituents and other aspects.Safety of 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride
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