On May 20, 2009, Schrittwieser, Joerg H.; Lavandera, Ivan; Seisser, Birgit; Mautner, Barbara; Kroutil, Wolfgang published an article.HPLC of Formula: 5034-06-0 The title of the article was Biocatalytic Cascade for the Synthesis of Enantiopure β-Azidoalcohols and β-Hydroxynitriles. And the article contained the following:
A three-step, two-enzyme, one-pot reaction sequence starting from prochiral α-chloroketones leading to enantiopure β-azidoalcs. and β-hydroxynitriles was described. Asym. bioreduction of α-chloroketones by hydrogen transfer catalyzed by an alc. dehydrogenase (ADH) established the stereogenic center in the first step to furnish enantiopure chlorohydrin intermediates. Subsequent biocatalyzed ring closure to the epoxide and nucleophilic ring opening with azide, N3-, or cyanide, CN-, both catalyzed by a nonselective halohydrin dehalogenase (Hhe), proceeded with full retention of configuration to give enantiopure β-azidoalcs. and β-hydroxynitriles, resp. Both enantiomers of various optically pure β-azidoalcs. and β-hydroxynitriles were synthesized. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009). The experimental process involved the reaction of trimethyloxosulphonium chloride(cas: 5034-06-0).HPLC of Formula: 5034-06-0
The Article related to chloroketones reduction ring closure opening azide cyanide enzyme catalyzed, alc azido nitrile hydroxy asym preparation biocatalytic cascade, General Organic Chemistry: Synthetic Methods and other aspects.HPLC of Formula: 5034-06-0
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics