On June 26, 1980, Schalke, Peter; Kleemann, Axel published a patent.Synthetic Route of 452-75-5 The title of the patent was Substituted acetonitriles. And the patent contained the following:
Aryl- or heteroarylacetonitriles were prepared by the reaction of methylarenes or -heteroarenes with ClCN in the gas phase at 550-850°; the reactants were injected sep. into the reactor at a temperature somewhat below the reaction temperature, and the reaction mixture was cooled immediately after leaving the reactor. Thus, 3-methylpyridine and ClCN were injected sep. into a reactor at 550°, and the mixture was heated to 680°, followed by treatment with aqueous NaOH to give 75% 3-pyridineacetonitrile of 98-9% purity. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Synthetic Route of 452-75-5
The Article related to areneacetonitrile, heteroareneacetonitrile, acetonitrile aryl heteroaryl, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Synthetic Route of 452-75-5
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics