On March 31, 2020, Ohsawa, Kosuke; Zhao, Hongbin; Tokunaga, Takuya; Thomas, Carys; Ganesan, A.; Masuda, Yuichi; Doi, Takayuki published an article.Category: chlorides-buliding-blocks The title of the article was Stereoselective synthesis of protected L-allo-enduracididine and L-enduracididine via asymmetric nitroaldol reaction. And the article contained the following:
The diastereoselecetive and scalable synthesis of cyclic guanidine-containing nonproteinoginic amino acids, enduracididines, has been achieved. Both diastereomers, L-allo-enduracididine and L-enduracididine, were prepared via catalyst-controlled asym. nitroaldol reaction with the aldehyde precursor derived from L-aspartic acid. The cyclic guanidine of di-Cbz-protected (Cbz = benzyloxycarbonyl) L-allo-enduracididine was fully protected with an allyl group to suppress nucleophilic side reactions. Introduced allyl group was efficiently removed via π-allylpalladium chem. without attaching the Cbz group on the cyclic guanidine moiety. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Category: chlorides-buliding-blocks
The Article related to enduracididine enantioselective synthesis cyclic guanidine containing amino acid, aspartic acid aldehyde nitroaldol reaction cobalt catalyst, Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.Category: chlorides-buliding-blocks
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics