On December 24, 2010, Jiang, Xiaolu; London, Emma K.; Morris, David J.; Clarkson, Guy J.; Wills, Martin published an article.Synthetic Route of 35444-44-1 The title of the article was Gold-catalysed cyclic ether formation from diols. And the article contained the following:
Gold(I) and (III) salts have been found to be highly effective at the catalysis of ether formation from alcs. Intramol. ether formation of a 1,5-diol was also achieved to give cyclic ethers, e.g. 2-phenyltetrahydropyran, with a stereoselectivity that indicates that an SN1 mechanism predominates. In an attempt to form a seven-membered ring, a stable 14-membered dimer product was also formed. Attempts to control the diastereoselectivity of the reaction using a chiral anionic counterion did not give products with a high de. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Synthetic Route of 35444-44-1
The Article related to gold catalyzed intramol etherification cyclic ether preparation diol reactant, Heterocyclic Compounds (One Hetero Atom): Pyrans and other aspects.Synthetic Route of 35444-44-1
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics