On May 24, 2000, there was a patent about piperidine aryloxymethyl preparation.Related Products of 452-75-5 The title of the patent was 4-[Aryl(aryloxy)methyl]piperidine derivatives and their use as serotonin and/or noradrenaline reuptake inhibitors. And the patent contained the following:
Title compounds I [R1, R2 = unsubstituted aryl or aryl mono- or polysubstituted with halogen (fluorine, chlorine, bromine, iodine), alkyl, alkoxy, cyano, trifluoromethoxy, trifluoromethyl, benzoyl, Ph, nitro, amino, aminoalkyl, aminoaryl and carbonylamino] are prepared Thus, 16.33 mmol tert-Bu 4-[(4-fluorophenyl)hydroxymethyl]-1-piperidinecarboxylate and 1.9 g 4-fluorophenol in 50 mL THF was treated with 5.0 g Ph3P, a DEAD solution (3.45 mL) in 10 mL THF was added, and after 3 h the product (I, R1 = R2 = 4-fluorophenyl) was isolated as the hydrochloride in 70% yield. Several optically active derivatives were also prepared The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Related Products of 452-75-5
The Article related to piperidine aryloxymethyl preparation, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Related Products of 452-75-5
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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics