On October 5, 1978, Henrick, Clive A.; Garcia, Barbara A. published a patent.Product Details of 452-75-5 The title of the patent was Amino acid esters and thiol esters. And the patent contained the following:
RR1NCR2R3COXR4 [R = cycloalkyl, cycloalkenyl, substituted Ph; R1 = H, alkyl, haloalkylcarbonyl, HCO; R2 = C2-5-alkyl, C2-5-alkenyl, C1-4-haloalkyl, C2-4-haloalkenyl, C3-4-cycloalkyl; R3 = H, F; X = O, S; R4 = CHR5R6 [R5 = H, CN, Me, CF3, CCH, CSNH2; R6 = substituted Ph, Q (R8 = H, alkyl; R9 = alkenyl, alkynyl, aralkyl; X1 = O, S)], CH2R10 [R10 = Q1 (R12R13 = alkylene, alkenylene; X2 = O, S), Q2 (R15 = H, alkyl, alkenyl, alkynyl, aralkyl; R16 = H, alkyl)], CH2CR17:CR18CH2R19 (R17 and R18 = H, Cl, F, Me; R17R18 = bond; R19 = Ph, OPh), CH(CCH)CR20:CHR21 (R20 = H, halo, Me, Et; R21 = allyl, propargyl, 3-butenyl, 3-butynyl, Ph, CH2Ph)] and their salts were prepared as pesticides. Thus, Me2CHCHBrCO2H was treated with SOCl2 to give the acid chloride, which was esterified with HOCH2C6H4OPh-m to give Me2CHCHBrCO2CH2C6H4OPh-m, which was aminated with PhNH2 to give PhNHCH(CHMe2)CO2CH2C6H4OPh-m. A great number of other N-substituted valine esters were also prepared Pesticide activity data are given. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Product Details of 452-75-5
The Article related to amino acid ester, pesticide amino acid ester, thioester amino acid, valine ester preparation pesticide, Synthesis of Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.Product Details of 452-75-5
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics