On April 28, 2021, Drozdowska, Marta; Tromans, Jay; Zhang, Bian; Jarling, Rene; Wilkes, Heinz; Golding, Bernard T. published an article.Synthetic Route of 98946-18-0 The title of the article was Defining Pathways of Anaerobic Alkane Oxidation: Synthesis of Enantiomers of 4-Methylalkanoic Acids and (2-Methylalkyl)malonic Acids. And the article contained the following:
A generic method for synthesis of either (R)- or (S)-acid in high enantiomeric purity from enantiomers of Me 3-hydroxy-2-methylpropionate was described for (R)- and (S)-4-methyloctanoic acid and (R)-4-methyldodecanoic acid. In a typical procedure silyl-protection of Me (S)-3-hydroxy-2-methylpropionate was followed by reduction of the ester to a primary alc., which was tosylated. Cu(I)-catalyzed cross-coupling of the tosylate with propylmagnesium chloride followed by deprotection, tosylation and base-induced reaction with di-t-Bu malonate, gave di-t-Bu (R)-(2-methylhexyl)malonate. Microwave heating of the diester in 2,2,2-trifluoroethanol gave a 42% overall yield of (R)-4-methyloctanoic acid, which was shown to be the enantiomer derived by metabolism of hexane by proteobacterium Aromatoleum sp. HxN1. Deprotection of the diester with trifluoroacetic acid gave (R)-2-(2-methylhexyl)malonic acid, which was the biol. precursor of (R)-4-methyloctanoic acid (via CoA esters). The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Synthetic Route of 98946-18-0
The Article related to methyl hydroxy methylpropionate enantioselective oxidation, methylalkanoic acid preparation, General Organic Chemistry: Synthetic Methods and other aspects.Synthetic Route of 98946-18-0
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics