Chen, Mao; Buchwald, Stephen L. published an article in 2013, the title of the article was Continuous-flow synthesis of 1-substituted benzotriazoles from chloronitrobenzenes and amines in a C-N bond formation/hydrogenation/diazotization/cyclization sequence.Product Details of 38939-88-7 And the article contains the following content:
We have developed an efficient and regiospecific synthesis of 1-substituted benzotriazoles from chloronitrobenzenes and amines by a C-N bond formation/hydrogenation/diazotization/cyclization sequence under continuous-flow conditions. Two approaches beginning either with an SnAr reaction or Pd catalysis were developed to prepare unsym. substituted benzotriazoles with a range of substituents. Of particular note is that benzotriazoles that bear various N-substituted groups, including alkyl, aryl, and heteroaryl, can all be efficiently and regiospecifically accessed with the described method. This protocol represents a successful example of a continuous-flow method with consecutive multiphase processes. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Product Details of 38939-88-7
The Article related to benzotriazoles regioselective synthesis continuous flow, chloronitrobenzene amine tandem reaction cn coupling hydrogenation diazotization cyclization, Heterocyclic Compounds (More Than One Hetero Atom): Triazines and other aspects.Product Details of 38939-88-7
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