On July 6, 2006, Brohm, Dirk; Diedrichs, Nicole; Huebsch, Walter; Schneider, Dirk; Froehlen, Britta-Nicole; Gerdes, Christoph; Gnoth, Mark Jean; Perzborn, Elisabeth; Voehringer, Verena published a patent.Category: chlorides-buliding-blocks The title of the patent was Preparation of azetidinylpyrazolines as anticoagulation agents. And the patent contained the following:
Title compounds I [X = (CH2)m; m = 0-3; Y = (CH2)n; n = 0-3; R1 = tetramic acid, NR5R6, etc.; R2 = Me, cycloalkyl, Ph, etc.; R3 = substituted Ph, thienyl; A = bond, O; R5 = H, Me, Et, etc.; R6 = H, Me, Et, etc.] and their pharmaceutically acceptable salts and formulations were prepared For example, N-acylation of 3-propylazetidine with phenol ester II afforded azetidinylpyrazoline III in 72% yield. In protease activated receptor 1 assays, 6-examples of compounds I exhibited IC50 values ranging from 14-395 nM. The experimental process involved the reaction of 3-(4-Chlorophenoxy)azetidine hydrochloride(cas: 490021-97-1).Category: chlorides-buliding-blocks
The Article related to azetidinylpyrazoline preparation protease activated receptor par1 anticoagulation agent, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazoles and other aspects.Category: chlorides-buliding-blocks
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics