On December 31, 1992, Boeren, S.; Tyrakowska, B.; Vervoort, J.; De Hoffman, E.; Teunis, K.; Van Veldhuizen, A.; Rietjens, I. M. C. M. published an article.Related Products of 38939-88-7 The title of the article was Rat liver microsomal metabolism of 2-halogenated 4-methylanilines. And the article contained the following:
Rat liver microsomal metabolism of 2-fluoro-, 2-chloro-, and 2-bromo-4-methylaniline was investigated using HPLC. Metabolites identified include products from side-chain C-hydroxylation (benzyl alcs. and benzaldehydes) and N-hydroxylation (hydroxylamines and nitroso derivatives). Aromatic ring hydroxylation was not a major reaction pathway. A new type of microsomal metabolite was detected which was identified as a secondary amine, i.e. a halogenated N-(4-aminobenzyl)-4-methylaniline. In addition to these products azoxy, azo and hydrazo derivatives were formed. Benzyl alcs. and halogenated N-(4-aminobenzyl)-4-methylanilines were the major microsomal metabolites for all 3 2-halogenated 4-methylanilines. Quantification of the metabolite patterns demonstrated an influence of the type of halogen substituent on the rate of microsomal metabolism The rate of side-chain C-hydroxylation increases in the order 2-fluoro-4-methylaniline < 2-chloro-4-methylaniline < 2-bromo-4-methylaniline. The rate of N-hydroxylation increases from 2-bromo-4-methylaniline < 2-fluoro-4-methylaniline < 2-chloro-4-methylaniline. That 2-chloro-4-methylaniline is N-hydroxylated to a larger extent is in accordance with its greater mutagenicity, twice that of 2-bromo-4-methylaniline. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Related Products of 38939-88-7
The Article related to liver microsome halogenated methylaniline metabolism, Toxicology: Carcinogens, Mutagens, and Teratogens and other aspects.Related Products of 38939-88-7
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