On December 26, 2000, Bell, Stanley Charles; De Vivo, Michael; Hopper, Allen; Isaac, Methvin; O’Brien, Anne; Ognyanov, Vassil Ilya; Schumacher, Richard published a patent.Application In Synthesis of 4-Chloro-2-fluorotoluene The title of the patent was Preparation of amino acid derivatives as glycine transport inhibitors. And the patent contained the following:
Compounds Ar1Ar2CR3-X-Y-CH(NR4R5)CO2R6 [Ar1, Ar2 = (un)substituted aryl; R3 = H, (un)substituted aryl; R4, R5 = H, alkyl, alkanoyl, benzoyl and benzyl; R6 = H, alkyl; X = S, SO, SO2, NR, CRR’, where R and R’ = H, alkyl, aryl, aralkyl; Y is a methylene or ethylene linking element, optionally substituted by an alkyl or Ph group (with provisos)] or their salts, solvates or hydrates were prepared as glycine transport inhibitors. Thus, S-(4-ethyl-4′-fluorodiphenyl)methyl-L-cysteine was prepared by reaction of 4-ethyl-4′-fluorodiphenylmethanol with L-cysteine. Compounds of the invention were tested for inhibition of glycine transport and displayed a plC50 of ∼ 4-8.5. Preferred compounds showed selectivity for the inhibition of glycine transport via GlyT-2 vs. GlyT-1. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Application In Synthesis of 4-Chloro-2-fluorotoluene
The Article related to amino acid derivative preparation inhibitor glycine transport, Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.Application In Synthesis of 4-Chloro-2-fluorotoluene
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Chloride – Wikipedia,
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