On March 5, 2022, Ahmad, Iqrar; Akand, Sazedur Rahman; Shaikh, Matin; Pawara, Rahul; Manjula, S. N.; Patel, Harun published an article.COA of Formula: C7H6ClNO2 The title of the article was Synthesis, molecular modelling study of the methaqualone analogues as anti-convulsant agent with improved cognition activity and minimized neurotoxicity. And the article contained the following:
In the current research, methaqualone derivatives were synthesized and assessed for their anti-convulsant activity. Among them, compounds 3, 4, 6, 7 and 11 exhibited significant anti-convulsant activities with ED50 values of 132.23 mg/kg, 120.34 mg/kg, 100.78 mg/kg, 145.89 mg/kg, and 148.46 mg/kg, resp. The toxicity profiling (TD50) of these compounds (3, 4, 6, 7 and 11) demonstrated that these drugs caused only a minor neurol. impairment. The PI scores of these compounds (3, 4, 6, 7 and 11) were higher than the reference drug (methaqualone PI: 1.99). The acetylcholinesterase enzyme level is significantly reduced in these compounds, indicating the enhancement of cognition activity. Pharmacophoric modeling and mol. docking studies against the human GABA-A receptor are in close agreement with each other. Mol. dynamic simulation of compound 6 indicates that it remains stable with the human GABA-A receptor for a 100 ns time span. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).COA of Formula: C7H6ClNO2
The Article related to methaqualone anticonvulsant cognition neurotoxicity mol docking, Placeholder for records without volume info and other aspects.COA of Formula: C7H6ClNO2
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