Zhou, Jiayu; Liu, Dan; Bai, Chaolumen; Bao, Agula; Muschin, Tegshi; Baiyin, Menghe; Bao, Yong-Sheng published an article in 2021, the title of the article was Transient directing group controlled regiodivergent C(sp3)-H and C(sp2)-H polyfluoroalkoxylation of aromatic aldehydes.Reference of 2-Amino-4-chlorobenzoic acid And the article contains the following content:
A novel method for achieving regiodivergent C(sp3)-H and C(sp2)-H polyfluoroalkoxylation in the o-Me benzaldehydes R-2-MeC6H3CHO (R = 3-Me, 4-MeO, 5-Br, etc.) framework by altering the transient directing group is disclosed. Using palladium as the catalyst and [F+] reagents as bystanding oxidants, various regioisomeric polyfluoroalkoxylated benzaldehydes R-6-C(CF3)2O-2-MeC6H2CHO and R-2-C(CF3)2OCH2C6H3CHO were prepared It is proposed that the selectivity is governed by the size of the palladacycle which is generated from Pd-chelation with different transient directing groups and helps in harnessing palladium with the benzyl C(sp3)-H or C(sp2)-H bonds of o-Me benzaldehydes. These findings provide an avenue for controlled regiodivergent C(sp3)-H and C(sp2)-H functionalization reactions. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Reference of 2-Amino-4-chlorobenzoic acid
The Article related to benzaldehyde polyfluoroalkoxy preparation regioselective, methyl benzaldehyde hexafluoroisopropanol polyfluoroalkoxylation transient directing group palladium catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ethers, Sulfides, and The Corresponding Onium Compounds and other aspects.Reference of 2-Amino-4-chlorobenzoic acid
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