On September 18, 2013, Zhou, Jian published a patent.HPLC of Formula: 38939-88-7 The title of the patent was One-pot serial synthesis method for oxindole. And the patent contained the following:
The title method comprises the steps of: sequentially adding malonate, alkali, first solvent, reducing agent, second solvent, and substituted o-nitro halogenated benzene, performing aromatic nucleophilic substitution, deesterification, and reducing ring-closing reactions in turn, and separating by column chromatog. to obtain oxindole. The byproduct metal salt of the aromatic nucleophilic substitution reaction can be directly used as an accelerator for the deesterification. The method has the advantages of good substrate universality, wide sources of raw materials, low cost, mild reaction condition, simple operation, and no environmental pollution, and is applicable for large-scale industrial production The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).HPLC of Formula: 38939-88-7
The Article related to oxindole preparation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.HPLC of Formula: 38939-88-7
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics