On May 10, 2017, Zhang, Songlin; Yu, Zelong published a patent.Recommanded Product: 38939-88-7 The title of the patent was Process for preparing indole and derivative. And the patent contained the following:
This invention provides a process for the preparation of indole and derivative I and II [wherein R = Me, OMe, CF3, halo, or Ph], which comprises (1) adding catalyst, ligand and base to the reaction tube, performing reaction of mixed solution of β-hydroxy ketone or ester Me2C(OH)CH2COR’ [wherein R’ = Me, Ph, or OEt] and 1-halo-2-nitrobenzenes III [wherein R as defined above; X = Cl, Br, I, or OTf] under the protection of nitrogen in oil-bath pot of 90-120 °C for 3-8 h, cooling to room temperature, extracting, washing, drying, and performing chromatog. to obtain IV, and (2) adding reducing agent system and solvent to the reaction tube, reacting at 60-100 °C for 3-8 h, extracting, washing, drying, and performing chromatog. to obtain the target product indole and derivative thereof. The invention has low cost, high yield, simple process and little pollution. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Recommanded Product: 38939-88-7
The Article related to preparation indole synthesis, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Recommanded Product: 38939-88-7
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics