Zhang, Song-Lin; Yu, Ze-Long published an article in 2016, the title of the article was Divergent synthesis of indoles, oxindoles, isocoumarins and isoquinolinones by general Pd-catalyzed retro-aldol/α-arylation.Quality Control of 2-Chloro-4-methyl-1-nitrobenzene And the article contains the following content:
Divergent synthesis of indoles I (R = H, 6-CH3, 5-F, etc.; R1 = CH3, C6H5), oxindoles II, isocoumarins e.g., III and isoquinolinones IV (R2 = CH3, C6H5) is described in this report by using a general Pd-catalyzed tandem reaction of β-hydroxy carbonyl compounds R3C(O)CH2C(R4)(OH)CH3 (R3 = CH3, C6H5, OCH3CH2; R4 = CH3, C6H5) with aryl halides bearing an ortho-nitro, -ester or -cyano substituent e.g., Me 2-chloropyridine-3-carboxylate. A key retro-aldol/α-arylation reaction is involved that merges classic Pd cross-coupling chem. with novel Pd-promoted retro-aldol C-C activation to produce α-arylated ketones or esters. Subsequent intramol. condensation of the carbonyl with the ortho-synthon gives target heterocycles I, II, e.g., III and IV. The use of common, com. available and cheap substrates and catalyst system adds addnl. synthetic advantages to the conceptual significance. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Quality Control of 2-Chloro-4-methyl-1-nitrobenzene
The Article related to indole oxindole isocoumarin isoquinolinone preparation, aryl halide hydroxy carbonyl retro aldol arylation palladium catalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Quality Control of 2-Chloro-4-methyl-1-nitrobenzene
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