On December 31, 2019, Yan, Jingbo; Li, Song; Zhong, Wu; Xiao, Junhai; Wang, Gang published a patent.Electric Literature of 38939-88-7 The title of the patent was Preparing method and application of Quetiapine analog. And the patent contained the following:
The title Quetiapine analog is shown in formula (I), wherein, m, n and p are independently integers of 0, 1, 2, 3 and 4; R1 and R2 are independently selected from H, halogen, nitro, cyano, hydroxy, etc.; R3 is 3-10-membered cycloalkyl, 3-membered heterocycloalkyl, etc.; R4 is H, cyano, C1-6 alkyl, etc.; R5 is H, C1-6 alkyl, C1-6 alkoxy, etc. The invented Quetiapine analog shows higher bioactivity than Quetiapine. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Electric Literature of 38939-88-7
The Article related to quetiapine antidepressant anxiolytic analgesic preparation, Heterocyclic Compounds (More Than One Hetero Atom): Eight- and Higher-Membered Rings and other aspects.Electric Literature of 38939-88-7
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics