On July 31, 2021, Wang, Kai; Wang, Binli; Liu, Xianghui; Fan, Hongjun; Liu, Yan; Li, Can published an article.SDS of cas: 89-77-0 The title of the article was Palladium-catalyzed enantioselective linear allylic alkylation of vinyl benzoxazinanones: An inner-sphere mechanism. And the article contained the following:
Palladium-catalyzed asym. allylic alkylation (AAA) of vinyl benzoxazinanones has become an important strategy for the synthesis of chiral nitrogen-containing heterocycle compounds However, the asym. synthesis of linear-selective products has rarely been reported. The simultaneous control of regio-, E/Z- and enantioselectivities constitutes a major challenge and inhibits the advancement of this chem. Herein, authors present a palladium-catalyzed AAA of vinyl benzoxazinanones with α-thiocyanato ketones, affording various chiral thiocyanates characterized with high linear-, E- and stereoselectivities. The reaction has a broad substrate scope and the chiral thiocyanates can be transformed to useful heterocycles. Exptl. and computational studies suggest an inner-sphere mechanism for AAA process, which results from the acidic and coordination effect of the nucleophilic substrates with palladium catalyst. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).SDS of cas: 89-77-0
The Article related to chiral thiocyanate preparation enantioselective computational study, vinyl benzoxazinanone thiocyanato ketone asym allylic alkylation palladium catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Nitriles, Isonitriles, and Acyl Cyanides and other aspects.SDS of cas: 89-77-0
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