On January 31, 2022, Tatevosyan, Stepan S.; Kotovshchikov, Yury N.; Latyshev, Gennadij V.; Lukashev, Nikolay V.; Beletskaya, Irina P. published an article.Synthetic Route of 89-77-0 The title of the article was Facile Access to Triazole-Fused 3,1-Benzoxazines Enabled by Metal-Free Base-Promoted Intramolecular C-O Coupling. And the article contained the following:
A convenient approach to assemble 1,2,3-triazole-fused 4 H-3,1-benzoxazines I (R = H, 6-Me, 7-I, 7,8-dimethoxy, etc.; R1 = H, Me, Ph; R2 = Bu, cyclopropyl, Ph, etc.) has been developed. Diverse alc.-tethered 5-iodotriazoles II (R3 = H, 6-Me, 5-I, 4,5-dimethoxy, etc.), readily accessible by a modified protocol of Cu-catalyzed (3+2)-cycloaddition, were utilized as precursors of the target fused heterocycles I. The intramol. C-O coupling proceeded efficiently under base-mediated transition-metal-free conditions, furnishing cyclization products I in yields up to 96%. Suppression of the competing reductive cleavage of the C-I bond was achieved by the use of Na2CO3 in acetonitrile at 100°C. This practical and cost-effective procedure features a broad substrate scope and valuable functional group tolerance. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Synthetic Route of 89-77-0
The Article related to triazole benzoxazine preparation, iodotriazolyl benzyl alc preparation intramol coupling, Heterocyclic Compounds (More Than One Hetero Atom): Oxazines (Including Morpholine) and other aspects.Synthetic Route of 89-77-0
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