Schnell, Simon D.; Hoff, Lukas V.; Panchagnula, Advaita; Wurzenberger, Maximilian H. H.; Klapotke, Thomas M.; Sieber, Simon; Linden, Anthony; Gademann, Karl published an article in 2020, the title of the article was 3-Bromotetrazine: labelling of macromolecules via monosubstituted bifunctional s-tetrazines.Application In Synthesis of tert-Butyl trichloroacetimidate And the article contains the following content:
Synthesis and first characterization of the novel chem. probe 3-bromotetrazine and establish its reactivity toward nucleophiles was reported. This led to the synthesis of several novel classes of 3-monosubstituted s-tetrazines, e.g., I. A remarkable functional group selectivity was observed and was utilized to site-selectively functionalize different complex mols. The stability of 3-bromotetrazine under the reaction conditions facilitated the development of a protocol for protein functionalization, which enabled a “minimal”, bifunctional tetrazine unit as a bio-orthogonal handle for inverse electron demand Diels-Alder reactions. Addnl., a novel tetrazine-based chem. probe was developed and its application in the context of thiol-targeted natural product isolation and labeling of mammalian cells was demonstrated. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Application In Synthesis of tert-Butyl trichloroacetimidate
The Article related to chem probe bromotetrazine preparation, Heterocyclic Compounds (More Than One Hetero Atom): Other 6-Membered Rings, Three Or More Hetero Atoms and other aspects.Application In Synthesis of tert-Butyl trichloroacetimidate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics