Rong, Nianxin; Yuan, Yongsheng; Chen, Huijie; Yao, Changguang; Li, Teng; Wang, Yantao; Yang, Weiran published an article in 2021, the title of the article was A practical route to 2-iodoanilines via the transition-metal-free and base-free decarboxylative iodination of anthranilic acids under oxygen.Name: 2-Amino-4-chlorobenzoic acid And the article contains the following content:
A simple and practical procedure for synthesizing 2-iodoanilines ArNH2 [Ar = 2-IC6H4, 2-I-4-BrC6H3, 2-I-4-MeOC6H3, etc.] had been developed. A series of highly regioselective 2-iodoanilines ArNH2 was obtained in satisfactory to good yields (of up to 90%) by carrying out the decarboxylative iodination of readily available anthranilic acids with inexpensive KI and I2 as halogen donors under transition-metal-free and base-free conditions. Oxygen was shown to be necessary for the transformation. This practical decarboxylative iodination route was operationally scalable and shown to exhibit high functional-group tolerance. Control experiments suggested that a radical pathway was involved in the transformation. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Name: 2-Amino-4-chlorobenzoic acid
The Article related to iodoaniline regioselective preparation, anthranilic acid oxygen decarboxylative iodination, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amines, Amine Oxides, Imines, and Quaternary Ammonium Compounds and other aspects.Name: 2-Amino-4-chlorobenzoic acid
Referemce:
Chloride – Wikipedia,
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