On March 19, 2021, Qi, Lin-Jun; Shi, Chong-Yang; Chen, Peng-Fei; Li, Long; Fang, Gang; Qian, Peng-Cheng; Deng, Chao; Zhou, Jin-Mei; Ye, Long-Wu published an article.Product Details of 89-77-0 The title of the article was Gold-Catalyzed 1,1-Carboalkoxylation of Oxetane-Ynamides via Exocyclic Metal Carbenes: Divergent and Atom-Economical Synthesis of Tricyclic N-Heterocycles. And the article contained the following:
Here, an unprecedented gold-catalyzed 1,1-carboalkoxylation of ynamides I (R1 = H, 4-Br, 5-Cl, 4-OMe, etc.; R2 = Ph, Me, 2-thienyl, etc.; R3 = Ts, Ms, benzenesulfonyl, etc.) for the generation of exocyclic gold carbenes via exo-cyclization under room temp was reported. Subsequent 1,2-N-migration and 1,2-H-migration into the gold carbenes lead to the divergent and atom-economical synthesis of valuable tetrahydrofuran-fused 1,4-dihydroquinolines II (R1 = H, 8-Br, 7-Cl, 8-OMe, etc.) and furoindolines III (R4 = H, 5-Br, 6-F, 5-OMe, etc.; R5 = Me, Et, n-Pr, etc.). Moreover, the asym. synthesis of these tricyclic N-heterocycles e.g., IV can be achieved by a chirality-transfer strategy, and the possibility of enantioselective cyclization via chiral gold-catalyzed kinetic resolution also emerges. In addition, the mechanistic rationale for this 1,1-carboalkoxylation, in particular accounting for the distinct migration into gold carbenes, is also strongly supported by theor. calculations The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Product Details of 89-77-0
The Article related to tricyclic nitrogen heterocycle preparation, ynamide oxetane preparation carboxylation gold catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Product Details of 89-77-0
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