On May 15, 2013, Polepally, Prabhakar R.; White, Kate; Vardy, Eyal; Roth, Bryan L.; Ferreira, Daneel; Zjawiony, Jordan K. published an article.Recommanded Product: 35444-44-1 The title of the article was Kappa-opioid receptor-selective dicarboxylic ester-derived salvinorin A ligands. And the article contained the following:
Salvinorin A, the active ingredient of the hallucinogenic plant Salvia divinorum is the most potent known naturally occurring hallucinogen and is a selective κ-opioid receptor agonist. To better understand the ligand-receptor interactions, a series of dicarboxylic ester-type of salvinorin A derivatives were synthesized and evaluated for their binding affinity at κ-, δ- and μ-opioid receptors. Most of the analogs show high affinity to the κ-opioid receptor. The Me malonyl derivative shows the highest binding affinity (Ki = 2 nM), while other analogs exhibit significant affinity for the κ-receptor (Ki = 21, 36 and 39 nM). The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Recommanded Product: 35444-44-1
The Article related to salvinorin a derivative preparation opioid receptor binding, Terpenes and Terpenoids: Diterpenes (C20), Including Gibberellins, Retinoids, Quassinoids, and Tocopherols and other aspects.Recommanded Product: 35444-44-1
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