Patel, Hiren; Chuckowree, Irina; Coxhead, Peter; Guille, Matthew; Wang, Minghua; Zuckermann, Alexandra; Williams, Robin S. B.; Librizzi, Mariangela; Paranal, Ronald M.; Bradner, James E.; Spencer, John published an article in 2014, the title of the article was Synthesis of hybrid anticancer agents based on kinase and histone deacetylase inhibitors.Reference of Methyl 6-chloro-6-oxohexanoate And the article contains the following content:
Fragments based on the VEGFR2i Semaxanib (SU5416, vascular endothelial growth factor receptor-2 inhibitor) and the HDACi (histone deacetylase inhibitor) SAHA (suberanilohydroxamic acid) have been merged to form a range of low mol. weight dual action hybrids. Vindication of this approach is provided by SAR, docking studies, in vitro cancer cell line and biochem. enzyme inhibition data as well as in vivo Xenopus data for the lead mol. I. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Reference of Methyl 6-chloro-6-oxohexanoate
The Article related to oxoindoline zinc binding group hybrid preparation anticancer docking, kinase histone deacetylase inhibitor, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Reference of Methyl 6-chloro-6-oxohexanoate
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