On April 27, 2022, Fischer, Pauline; Bultel-Ponce, Valerie; Guy, Alexandre; Gonzales, Ilyana; Conde, Pierre-Alexis; Galano, Jean-Marie; Durand, Thierry; Oger, Camille published an article.Electric Literature of 35444-44-1 The title of the article was Straightforward Syntheses of Phytoprostanes and Dihomo-phytoprostanes – Non-enzymatic Metabolites of γ-Linolenic, Dihomo-γ-linolenic and Stearidonic Acids. And the article contained the following:
γ-Linolenic (GLA; C18:3 n-6), dihomo-γ-linolenic (DGLA; C20:3 n-6) and stearidonic (SDA; C18:4 n-3) acids are found in several botanic and marine oils and are sustainable sources of omega-6 and omega-3 polyunsaturated fatty acids (PUFAs). During oxidative stress (pollution, UV, hydric or nutrient stress), lipid peroxidation occurred to produce non-enzymic oxylipins named phytoprostanes (PhytoPs). We report herein the first syntheses of six non-enzymic PUFA metabolites originated from GLA, DGLA and SDA peroxidation Our syntheses follow a straightforward synthetic pathway from enantiopure common intermediates (lactol or monoacetates), further used Horner-Wadsworth-Emmons and Wittig reactions to set up the side chains, and Corey-Bakshi-Shibata enantioselective reduction Our strategy once again proved to be highly efficient as the compounds were obtained after only 4 to 12 consecutive steps, starting from previously prepared intermediates, and in a range from 6.5 to 41.5% yield. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Electric Literature of 35444-44-1
The Article related to phytoprostane synthesis metabolite linolenic homolinolenic stearidonic acid peroxidation, Biomolecules and Their Synthetic Analogs: Prostaglandins and Other Arachidonic Acid Cascade Substances, Thromboxanes, Fatty Acids and other aspects.Electric Literature of 35444-44-1
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