On August 1, 2018, Zhou, Qian; You, Chaoqun; Zheng, Cong; Gu, Yawen; Gu, Hongchao; Zhang, Rui; Wu, Hongshuai; Sun, Baiwang published an article.Quality Control of 2-Chloro-4-nitrobenzoic acid The title of the article was 3-Nitroacridine derivatives arrest cell cycle at G0/G1 phase and induce apoptosis in human breast cancer cells may act as DNA-target anticancer agents. And the article contained the following:
DNA is considered to be one of the most promising targets for anticancer agents. Acridine analogs have anticancer activity based on DNA binding and topoisomerases inhibition. However, due to the side effects, resistance and low bioavailability, a few have entered into clin. usage and the mechanisms of action are not fully understood. Novel acridine derivatives are needed for effective cancer therapy. A series of novel 3-nitroacridine-based derivatives were synthesized, their DNA binding and anticancer activities were evaluated. The chem. modifications at position 9 of the 3-nitroacridine were crucial for DNA affinity, thus optimizing anticancer activity. UV-Vis and CD (CD) spectroscopy indicated interaction of compounds with DNA, and the binding modes were intercalation and groove binding. MTT assay and clonogenic assay showed that compounds 1, 2 and 3 had obvious cell growth inhibition effect. They induced cell apoptosis in human breast cancer cells in a dose-dependent manner, and exhibited anticancer effect via DNA damage as well as cell cycle arrest at G0/G1 phage. Using confocal fluorescent microscope, the apoptotic features were observed The results suggested that compounds 1-3 with high DNA binding affinity and good inhibitory effect of cancer cell proliferation can be developed as prime candidates for further chem. optimization. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Quality Control of 2-Chloro-4-nitrobenzoic acid
The Article related to breast cancer dna target anticancer agent 3 nitroacridine derivative, apoptosis cell cycle arrest g1 g0 phase, acridine derivatives, anticancer activity, apoptosis, dna binding, structure-activity relationship (sar), synthesis and other aspects.Quality Control of 2-Chloro-4-nitrobenzoic acid
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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics