Spinozzi, Eleonora; Bauer, Adriano; Maulide, Nuno published an article in 2019, the title of the article was A Mild Synthesis of Bicyclic Alkoxyoxazolium Salts from Proline and Pipecolic Acid Derivatives.Reference of Methyl 6-chloro-6-oxohexanoate And the article contains the following content:
A regio- and chemoselective preparation of bicyclic alkoxyoxazolium salts from amide derivatives of proline and pipecolic acid by electrophilic amide activation is reported. Mechanistic NMR experiments suggest an unusual role for the base and highlight the effect of substitution pattern of the substrates. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Reference of Methyl 6-chloro-6-oxohexanoate
The Article related to bicyclic alkoxyoxazolium salt preparation proline pipecolic electrophilic amide activation, amide activation, chemoselectivity, cycloaddition, oxazolium, synthesis design and other aspects.Reference of Methyl 6-chloro-6-oxohexanoate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics