On December 3, 2021, Pascoe, Cameron A.; Engelhardt, Daniel B.; Rosana, Albert Remus R.; van Belkum, Marco J.; Vederas, John C. published an article.HPLC of Formula: 98946-18-0 The title of the article was Methylene analogs of neopetrosiamide as potential antimetastatic agents: solid-supported syntheses using diamino diacids for pre-stapling of peptides with multiple disulfides. And the article contained the following:
Neopetrosiamide, a 28-residue peptide from Neopetrosia sp., contains three disulfide bonds and hinders mammalian tumor cell invasion. Proper connectivity of disulfide bonds is crucial for activity. Synthetic replacement of single disulfide bridges with methylene bridges gives active analogs. Pre-stapling of one ring enhances the correct formation of the remaining disulfides by reducing isomeric possibilities and possibly initiating the correct 3D fold. Cloning and expression of neopetrosiamide in E. coli affords access to the natural linear peptide. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).HPLC of Formula: 98946-18-0
The Article related to cyclic peptide neopetrosiamide methylene analog synthesis antimetastatic antitumor agent, diamino acid solid phase peptide synthesis coupling oxidative cyclization, natural product neopetrosiamide and other aspects.HPLC of Formula: 98946-18-0
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics