On June 9, 2016, Park, Chan Hee; Lee, Sang Hwi; Im, Junhwan; Lee, Soon Ok; Kim, Jongmin; Ko, Kwang Seok; Kim, Byungho; Kong, Minjung; Kim, Mi Sun; Moon, Hyung Jo published a patent.Name: 4-Chloro-2-fluorotoluene The title of the patent was Preparation of heterocyclic derivatives for preventing or treating diseases associated with the activation of STAT3 protein. And the patent contained the following:
The title compounds I [one of X1-X4 = C(Rx1), and the others = (independently) C(Rx2) or N; one of Y and Z = S or NH, and the other = CH or N; Rx1 = L1S(:O)(:Xs)Rs (wherein Xs = O or NH; L1 = (un)subsitituted CH2 or NH; Rs = alkyl, haloalkyl, alkoxyalkyl, etc.); Rx2 = H, halo, NO2, etc.; A and B = (independently) a monocyclic- or bicyclic-saturated or unsaturated C3-10 carbocycle or 5-12 membered heterocycle; R1 = H, halo, CN, etc.; R2 = H, halo, OH, etc.; R3 = O, NH, N(alkyl), N(OH); R4 = H, alkyl; or R4 is linked to R1 to form a chain; L2 = (un)substituted (CH2)m, (CH2)nO, O, etc. (m = 0-3; n = 1-3); p = 0-4, and, when p is 2 or higher, R1 moieties are the same as or different from each other; q = 0-4, and, when q is 2 or higher, R2 moieties are the same as or different from each other] which have an inhibitory effect on the activation of STAT3 protein, and are useful for the prevention or treatment of diseases associated with the activation of STAT3 protein, were prepared E.g., a multi-step synthesis of N-(3-chloro-5-(2-(3-ethoxy-5-(trifluoromethoxy)phenyl)propan-2-yl)phenyl)-5-(2-(methylsulfonyl)propan-2-yl)benzo[b]thiophene-2-carboxamide, starting from 3-chloro-5-nitrobenzoic acid, was described. Exemplified compounds I were evaluated on their inhibitory effect on the dimerization of STAT3 and STAT1 (data given). Pharmaceutical composition comprising compound I was disclosed. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Name: 4-Chloro-2-fluorotoluene
The Article related to heterocyclic amide preparation stat3 protein activation inhibitor antitumor antiinflammatory, benzothiophenecaboxamide preparation stat3 protein activation inhibitor antitumor antiinflammatory and other aspects.Name: 4-Chloro-2-fluorotoluene
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics