On May 20, 1995, Miyamoto, Yoshiko; Kohno, Hitoshi; Pfleiderer, Wolfgang; Boeger, Peter; Wakabayashi, Ko published an article.Application of 452-75-5 The title of the article was Synthesis of 1,2,4-triazolo[1,5-a]-1,3,5-triazine derivatives for phytotoxic activity. And the article contained the following:
Treatment of benzylideneaminoguanidines (I) with Et N-cyanoformimidate (II) in MeCN at room temperature gave 1-benzylideneamino-2-cyanoiminomethylguanidines (III). I (R1 = 2-F and 4-Cl, R2 = H, R3 = Me) and I (R1 = 4-Cl, R2 = H, R3 = Me) were treated with II directly to give 7-methylamino-2-halophenyl-1,2,4-triazolo[1,5-a]-1,3,5-triazines V (R1 = 2-F and 4-Cl, R2 = H, R3 = Me) and V (R1 = 4-Cl, R2 = H, R3 = Me) under similar conditions. III were readily cyclized to the corresponding 1,2-dihydro-1,2,4-triazolo[1,5-a]-1,3,5-triazines (IV) by brief heating in MeOH. IV were oxidized with iodine in EtOH to give the corresponding V. Phytotoxic activities of III, IV, and V were assayed using green microalgae, Scenedesmus acutus. V (R1 = 2-F and 4-Cl, R2 = R3 = H) and some other compounds were found to suppress the cell growth and chlorophyll formation of Scenedesmus, but those activities were still not good enough to be utilized as a herbicide or plant growth regulator. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Application of 452-75-5
The Article related to triazolotriazine synthesis phytotoxicity, condensation benzylideneaminoguanidine cyanoformimidate, cyclization benzylideneaminocyanoiminomethylguanidine, oxidation hydrotriazolotriazine and other aspects.Application of 452-75-5
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