On September 8, 2016, Masuda, Yuichi; Maruyama, Chitose; Kawabata, Kyuichi; Hamano, Yoshimitsu; Doi, Takayuki published an article.Application of 98946-18-0 The title of the article was Synthesis of (2S,3R,4R)-3,4-dihydroxyarginine and its inhibitory activity against nitric oxide synthase. And the article contained the following:
A synthesis of (2S,3R,4R)-3,4-dihydroxyarginine, a metabolic intermediate of streptothricin, was accomplished. The (3R,4R)-dihydroxy groups were constructed by asym. syn-dihydroxylation of (E)-alkene, which was obtained by cross-metathesis of allylamine and L-vinylglycine derivatives The synthesis of (2S,3S,4S)-3,4-dihydroxyarginine was also achieved in the same manner. The (2S,3R,4R)-3,4-dihydroxyarginine exhibited inhibitory activity against inducible nitric oxide synthase, unlike (2S,3S,4S)-3,4-dihydroxyarginine. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Application of 98946-18-0
The Article related to arginine dihydroxy enantioselective diastereoselective synthesis metabolic intermediate streptothricin, nitric oxide synthase inhibitor dihydroxyarginine, allylamine vinylglycine cross metathesis alkene asym syn dihydroxylation and other aspects.Application of 98946-18-0
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics