On May 24, 2012, Lundgren, Rylan J.; Stradiotto, Mark published a patent.Product Details of 452-75-5 The title of the patent was Preparation of amines, hydrazones, hydrazines, and indazoles by hydroamination or cross-coupling reactions catalyzed by palladium or gold in the presence of a phosphine ligand. And the patent contained the following:
The invention provides compounds and ligands of formula I that are useful in transition metal catalyzed cross-coupling reactions. Compounds of formula I wherein R1 and R2 are independently t-Bu, cyclohexyl, 2-tolyl, 1-adamantyl; R3 and R4 are independently C1-5 alkyl; R3R4 taken together to form a 4- to 10-membered heterocyclyl; each X is independently N and CR5; each X1 is independently N and CR6; R5 is H, Me, OME, halo, and CF3; R6 is H, Me, OMe, NMe2, halo and CF3; vicinal R5R6 may be taken together to form a 5- to 7-membered heterocyclic or carbocyclic ring; provided that no more than one of each X and X1 is N; are claimed. For example, the compounds and ligands of the invention are useful in palladium or gold catalyzed cross-coupling reactions. Ligand II was used in the palladium-catalyzed cross-coupling of chlorobenzene with hydrazine followed by condensation to give diphenylhhydrazone. The experimental process involved the reaction of 4-Chloro-2-fluorotoluene(cas: 452-75-5).Product Details of 452-75-5
The Article related to aryl halide amine cross coupling palladium phosphine, arylamine preparation, indazole preparation, hydrazone preparation, hydrazine preparation, palladium phosphine cross coupling catalyst and other aspects.Product Details of 452-75-5
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics