On March 17, 2021, Li, Xiaoyu; Golden, Jennifer E. published an article.HPLC of Formula: 89-77-0 The title of the article was Construction of N-Boc-2-Alkylaminoquinazolin-4(3H)-Ones via a Three-Component, One-Pot Protocol Mediated by Copper(II) Chloride that Spares Enantiomeric Purity. And the article contained the following:
A multicomponent procedure integrating anthranilic acids, N-Boc-amino acids and amines in the presence of methanesulfonyl chloride, N-methylimidazole, and copper(II) chloride was developed to mildly afford N-Boc-2-alkylaminoquinazolin-4(3H)-ones, e.g., I, with excellent preservation of enantiomeric purity (>99% ee). Copper(II) chloride was essential to retaining enantiopurity and reaction component structural changes were well tolerated, resulting in an efficient, all-in-one procedure that promoted sequential coupling, lactonization, aminolysis and cyclization in good yields. The method was applied to the rapid assembly of four key intermediates used in the synthesis of high profile quinazolinones, including several PI3K inhibitor drugs. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).HPLC of Formula: 89-77-0
The Article related to boc alkylaminoquinazolinone preparation enantioselective, anthranilic acid amino aniline copper chloride mediated multicomponent, pi3 kinase, copper-mediated, enantiopurity, quinazolinone, racemization and other aspects.HPLC of Formula: 89-77-0
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics