Jerhaoui, Soufyan; Djukic, Jean-Pierre; Wencel-Delord, Joanna; Colobert, Francoise published an article in 2017, the title of the article was Stereoselective Sulfinyl Aniline-Promoted Pd-Catalyzed C-H Arylation and Acetoxylation of Aliphatic Amides.Related Products of 35444-44-1 And the article contains the following content:
Stereoselective functionalization of aliphatic C-H bonds presents a great challenge. Following this target, we disclose herein an original strategy towards direct arylation of aliphatic chains at β-methylene position based on a use of amide-sulfoxide bicoordinating directing group. Although moderate to high chiral induction (up to 9:1 d.r.) is achieved, diastereomerically pure compounds may be afforded by simple separation of diastereomeric products by silica gel chromatog. Accordingly, this reaction allows preparation of a large scope of high-value scaffolds in synthetically useful yields while recyclable character of our chiral auxiliary brings an addnl. benefit. A potential of this methodol. to build up original mols. by sequential diarylation and expedient (two step) synthesis of a biol. active compound are further disclosed. Finally a first example of stereoselective direct acetoxylation of aliphatic chains is reported. Thus, e.g., treatment of valeric acid derivative I with 4-iodonitrobenzene in presence of Pd(OAc)2 and AgOAc in PhMe/HFIP afforded arylated product II (85% conversion, 3:2 d.r.). The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Related Products of 35444-44-1
The Article related to stereoselective palladium catalyzed arylation acetoxylation aliphatic amide, sulfinyl aniline directing group chiral auxiliary stereoselective arylation acetoxylation, c−h activation, aliphatic substrates, bixoordinating dg, direct arylation, sulfoxide and other aspects.Related Products of 35444-44-1
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