Huang, Yong; Zhang, Lu; Wang, Meng; Li, Chengze; Zheng, Wei; Chen, Hualong; Liang, Ying; Wu, Zehui published an article in 2022, the title of the article was Optimization of Precursor Synthesis Conditions of (2S,4S)4-[18F]FPArg and Its Application in Glioma Imaging.Application In Synthesis of tert-Butyl trichloroacetimidate And the article contains the following content:
Although the tracer (2S,4S)4-[18F]FPArg is expected to provide a powerful imaging method for the diagnosis and treatment of clin. tumors, it has not been realized due to the low yield of chem. synthesis and radiolabeling. A simple synthetic method for the radiolabeled precursor of (2S,4S)4-[18F]FPArg in stable yield was obtained by adjusting the sequence of the synthetic steps. Furthermore, the biodistribution experiments confirmed that (2S,4S)4-[18F]FPArg could be cleared out quickly in wild type mouse. Cell uptake experiments and U87MG tumor mouse microPET-CT imaging experiments showed that the tumor had high uptake of (2S,4S)4-[18F]FPArg and the clearance was slow, but (2S,4S)4-[18F]FPArg was rapidly cleared in normal brain tissue. MicroPET-CT imaging of nude mice bearing orthotopic HS683-Luc showed that (2S,4S)4-[18F]FPArg can penetrate blood-brain barrier and image gliomas with a high contrast. Therefore, (2S,4S)4-[18F]FPArg is expected to be further applied in the diagnosis and efficacy evaluation of clin. glioma. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Application In Synthesis of tert-Butyl trichloroacetimidate
The Article related to carbamimidoyl carboxyaminomethyl carboxyamino fluoroheptanoic acid glioma imaging optimization, (2s,4s)4–[18f]fparg, amino acid, glioma imaging, positron emission tomography, tracer and other aspects.Application In Synthesis of tert-Butyl trichloroacetimidate
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