On May 1, 2019, Huang, Yong; Liu, Song; Wu, Renbo; Zhang, Lifang; Zhang, Yan; Hong, Haiyan; Zhang, Aili; Xiao, Hao; Liu, Yajing; Wu, Zehui; Zhu, Lin; Kung, Hank F. published an article.Recommanded Product: tert-Butyl trichloroacetimidate The title of the article was Synthesis and preliminary evaluation of a novel glutamine derivative: (2S,4S)4-[18F]FEBGln. And the article contained the following:
We report the preparation of a novel glutamine derivative, (2S,4S)-2,5-diamino-4-(4-(2-fluoroethoxy)benzyl)-5-oxopentanoic acid, (2S, 4S)4-[18F]FEBGln ([18F]4), through efficient organic and radiosyntheses. In vitro assays of [18F]4 using MCF-7 cells showed that it entered cells via multiple amino acid transporter systems including system L and ASC2 transporters but not through the system A transporter. [18F]4 showed promising properties for tumor imaging and may serve as a lead compound for further optimizing and targeting the system L transporter associated with enhanced glutamine metabolism in cancer cells. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Recommanded Product: tert-Butyl trichloroacetimidate
The Article related to glutamine derivative tumor imaging agent diamino fluoroethoxybenzyl oxopentanoic acid, amino acid transporter system uptake chirality, amino acid, glutamine, radiosynthesis, synthesis, transporter and other aspects.Recommanded Product: tert-Butyl trichloroacetimidate
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Chloride – Wikipedia,
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