On November 13, 2003, Heppner, Philip D.; Charles, Leslie J.; Dellaria, Joseph F.; Merrill, Bryon A.; Mickelson, John W. published a patent.Recommanded Product: 2-Chloro-4-methyl-1-nitrobenzene The title of the patent was Preparation of aryl ether substituted imidazoquinolines as immune response modifiers. And the patent contained the following:
The title compounds [I; X = (CH2)2, CHEtCH2, etc.; R1 = alkenyl, aryl, R4-aryl; R2 = H, alkyl, alkenyl, etc.; R4 = alkyl, alkenyl which may be interrupted by one or more O atoms; R3 = H, alkyl; n = 0-4; R = alkyl, alkoxy, OH, etc.] that contain ether and aryl or alkenyl functionality at the 1-position, and are useful as immune response modifiers, were prepared E.g., a multi-step synthesis of I [X = (CH2)2; R1 = CH2CCH; R2 = H; n = 0] which showed the lowest effective concentration of 0.12 μM and 1.11 μM to induce biosynthesis of interferon α and TNFα in human cells, resp., was given. The compounds I can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases. The pharmaceutical composition comprising the compound I is claimed. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Recommanded Product: 2-Chloro-4-methyl-1-nitrobenzene
The Article related to imidazoquinoline aryl ether preparation immunomodulator antiviral antitumor, cytokine interferon tnf alpha biosynthesis inducer imidazoquinoline preparation, tumor necrosis factor alpha biosynthesis inducer imidazoquinoline preparation and other aspects.Recommanded Product: 2-Chloro-4-methyl-1-nitrobenzene
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics