On February 16, 2018, Hawkins, Paige M. E.; Giltrap, Andrew M.; Nagalingam, Gayathri; Britton, Warwick J.; Payne, Richard J. published an article.Computed Properties of 98946-18-0 The title of the article was Total synthesis of Ecumicin. And the article contained the following:
The first total synthesis of the potent anti-mycobacterial cyclic depsipeptide natural product ecumicin is described. Synthesis was achieved via a solid-phase strategy, incorporating the synthetic non-proteinogenic amino acids N-methyl-4-methoxy-L-tryptophan and threo-β-hydroxy-L-phenylalanine into the growing linear peptide chain. The synthesis employed key on-resin esterification and dimethylation steps as well as a final macrolactamization between the unusual N-methyl-4-methoxy-L-tryptophan unit and a bulky N-methyl-L-valine residue. The synthetic natural product possessed potent antimycobacterial activity against the virulent H37Rv strain of Mycobacterium tuberculosis (MIC90 = 312 nM). The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Computed Properties of 98946-18-0
The Article related to natural product cyclic depsipeptide antimycobacterial agent tuberculostatic drug, solid phase peptide synthesis esterification dimethylation macrolactamization steric effect and other aspects.Computed Properties of 98946-18-0
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics