On April 23, 2009, Glatthar, Ralf; Carcache, David published a patent.Computed Properties of 38939-88-7 The title of the patent was Preparation of benzimidazoles and related compounds as modulators of metabotropic glutamate receptor-5 for treating gastrointestinal, urinary, and nervous system disorders. And the patent contained the following:
The present invention relates to novel benzimidazole derivatives, their preparation, their use as pharmaceuticals and pharmaceutical compositions containing them, wherein the compounds have the Formula I (wherein X1 -X4 each independently represent CR2 or N; R2 is H, halo, OH. etc.; R1 is C1-6alkyl, C1-6halogenalkyl, C3-12cycloalkyl, etc.; B is aryl, nitrogen-containing ring, etc.; C is a 5-12-membered aromatic (un)substituted ring system that may contain hetero atoms) and salts, solvates, hydrates and N-oxides thereof. Synthetic procedures for preparing I are exemplified. Example compound II, prepared by reacting 3-chloro-5-iodo-N-2-propylbenzene-1,2-diamine and 5-chloro-6-(6-methylpyridin-3-ylamino)nicotinoyl chloride, caused 97% inhibition of mGluR5 activity at 0.1 μM. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Computed Properties of 38939-88-7
The Article related to benzimidazole derivative preparation therapeutic metabotropic glutamate receptor 5 modulator, benzimidazole derivative mglur5 modulator gastrointestinal urinary nervous system disorder and other aspects.Computed Properties of 38939-88-7
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics