Fandrick, Keith R.; Li, Wenjie; Zhang, Yongda; Tang, Wenjun; Gao, Joe; Rodriguez, Sonia; Patel, Nitinchandra D.; Reeves, Diana C.; Wu, Jiang-Ping; Sanyal, Sanjit; Gonnella, Nina; Qu, Bo; Haddad, Nizar; Lorenz, Jon C.; Sidhu, Kanwar; Wang, June; Ma, Shengli; Grinberg, Nelu; Lee, Heewon; Tsantrizos, Youla; Poupart, Marc-Andre; Busacca, Carl A.; Yee, Nathan K.; Lu, Bruce Z.; Senanayake, Chris H. published an article in 2015, the title of the article was Concise and practical asymmetric synthesis of a challenging atropisomeric HIV integrase inhibitor.Recommanded Product: 98946-18-0 And the article contains the following content:
A practical and efficient synthesis of a complex chiral atropisomeric HIV integrase inhibitor, I, has been accomplished. The combination of a copper-catalyzed acylation along with the implementation of the biaryl monophosphorus (BI-DIME) ligands for a ligand-controlled Suzuki cross-coupling and an unprecedented bis(trifluoromethane)sulfonamide-catalyzed tert-butylation rendered the synthesis of this complex mol. robust, safe, and economical. Furthermore, the overall synthesis was conducted in a diastereoselective fashion with respect to the imbedded atropisomer. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Recommanded Product: 98946-18-0
The Article related to bisquinoline integrase inhibitor diastereoselective preparation thermal equilibration, boronic acid aryl chloride suzuki cross coupling, suzuki couplings, acylation, asymmetric synthesis, phosphine ligands, tert-butylation and other aspects.Recommanded Product: 98946-18-0
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics