On April 16, 2021, Fairuz Binte Sheikh Ismail, Siti Nur; Yang, Binmiao; Zhao, Yu published an article.Application In Synthesis of 2-Amino-4-chlorobenzoic acid The title of the article was Access to 5,6-Spirocycles Bearing Three Contiguous Stereocenters via Pd-Catalyzed Stereoselective [4 + 2] Cycloaddition of Azadienes. And the article contained the following:
We present herein a highly diastereo- and enantioselective Pd-catalyzed [4 + 2] cycloaddition of benzofuran-derived azadienes with vinyl benzoxazinanones, which represents a rare highly stereoselective cycloaddition of this class of fused azadienes as a two-atom synthon. The use of a phosphoramidite ligand bearing a chiral secondary amine with a simple biphenyl backbone proved to be the key to construct the novel spirocyclic tetrahydroquinoline scaffold containing three contiguous stereocenters in high enantioselectivity. The experimental process involved the reaction of 2-Amino-4-chlorobenzoic acid(cas: 89-77-0).Application In Synthesis of 2-Amino-4-chlorobenzoic acid
The Article related to vinyl benzoxazinanone azadiene palladium phosphoramidite ligand diastereoselective enantioselective cycloaddition, spirocyclic tetrahydroquinoline stereoselective preparation and other aspects.Application In Synthesis of 2-Amino-4-chlorobenzoic acid
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