Dowman, Luke J.; Agten, Stijn M.; Ripoll-Rozada, Jorge; Calisto, Barbara M.; Pereira, Pedro Jose Barbosa; Payne, Richard J. published an article in 2021, the title of the article was Synthesis and evaluation of peptidic thrombin inhibitors bearing acid-stable sulfotyrosine analogs.Formula: C6H10Cl3NO And the article contains the following content:
Tyrosine sulfation is an important post-translational modification of peptides and proteins which underpins and modulates many protein-protein interactions. In order to overcome the inherent instability of the native modification, we report the synthesis of two sulfonate analogs and their incorporation into two thrombin-inhibiting sulfopeptides. The effective mimicry of these sulfonate analogs for native sulfotyrosine was validated in the context of their thrombin inhibitory activity and binding mode, as determined by X-ray crystallog. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Formula: C6H10Cl3NO
The Article related to peptide thrombin inhibitor synthesis sulfotyrosine, sulfonated aryl iodide negishi cross coupling iodoalanine, solid phase peptide synthesis microwave, thrombin crystal structure inhibitor mol docking and other aspects.Formula: C6H10Cl3NO
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Chlorides – an overview | ScienceDirect Topics