On November 15, 2019, De Luca, Stefania; Digilio, Giuseppe; Verdoliva, Valentina; Tovillas, Pablo; Jimenez-Oses, Gonzalo; Peregrina, Jesus M. published an article.Category: chlorides-buliding-blocks The title of the article was Lanthionine peptides by S-alkylation with substituted cyclic sulfamidates promoted by activated molecular sieves: Effects of the sulfamidate structure on the yield. And the article contained the following:
A green and efficient method for preparing lanthionine peptides by a highly chemoselective and stereochem. controlled procedure is presented. It involves an S-alkylation reaction, promoted by activated mol. sieves, on chiral cyclic sulfamidates, both N-protected and unprotected. Of note, the reaction yield was high also for cyclic sulfamidates bearing a free amine group, while other strategies failed to achieve a ring-opening nucleophilic reaction with N-unprotected substrates. To prove the feasibility of the procedure, the synthesis of a thioether ring B mimetic of the natural lantibiotic haloduracin β was performed. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Category: chlorides-buliding-blocks
The Article related to lanthionine peptide enantioselective synthesis green chem, solid phase peptide synthesis, chiral cyclic sulfamidate s alkylation thioetherification cyclization, thioether ring b preparation natural lantibiotic beta haloduracin and other aspects.Category: chlorides-buliding-blocks
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics