On September 30, 2017, Castillo-Pazos, Durbis J.; MacMillan, Derek published an article.Computed Properties of 98946-18-0 The title of the article was Investigation of cysteine as an activator of side-chain N→S acyl transfer and tail-to-side-chain cyclization. And the article contained the following:
N→S Acyl transfer is a popular method for the post-synthesis production of peptide Cα-thioesters for use in native chem. ligation and for the synthesis of head-to-tail cyclic peptides. Meanwhile thioester formation at the side chain of aspartic or glutamic acids, leading to tail-to-side-chain-cyclized species, is less common. Herein we explore the potential for cysteine to function as a latent thioester when appended to the side chain of glutamic acid. Initial insights gained through study of C-terminal β-alanine as a model for the increased chain length were ultimately applied to peptide macrocyclization. Our results emphasize the increased barrier to acyl transfer at the glutamic acid side chain and indicate how a slow reaction, facilitated by cysteine itself, may be accelerated by fine-tuning of the stereoelectronic environment. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Computed Properties of 98946-18-0
The Article related to cyclic peptide synthesis cysteine activator thioester macrocyclization kinetics, solid phase peptide synthesis acyl transfer macrocyclization ncl, agardhipeptin a analog cyclization and other aspects.Computed Properties of 98946-18-0
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics