On June 3, 2022, Bolduc, Trevor G.; Lee, Cayo; Chappell, William P.; Sammis, Glenn M. published an article.Safety of tert-Butyl trichloroacetimidate The title of the article was Thionyl fluoride-mediated one-pot substitutions and reductions of carboxylic acids. And the article contained the following:
Thionyl fluoride (SOF2) is an underutilized reagent that is yet to be extensively studied for its synthetic applications. We previously reported that it is a powerful reagent for both the rapid syntheses of acyl fluorides and for one-pot peptide couplings, but the full scope of these nucleophilic acyl substitutions had not been explored. Herein, we report one-pot thionyl fluoride-mediated syntheses of peptides and amides (35 examples, 45-99% yields) that were not explored in our previous study. The scope of thionyl fluoride-mediated nucleophilic acyl substitutions was also expanded to encompass esters (24 examples, 64-99% yields) and thioesters (11 examples, 24-96% yields). In addition, we demonstrate that the scope of thionyl fluoride-mediated one-pot reactions can be extended beyond nucleophilic acyl substitutions to mild reductions of carboxylic acids using NaBH4 (13 examples, 33-80% yields). The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Safety of tert-Butyl trichloroacetimidate
The Article related to peptide amide one pot synthesis thionyl fluoride mediated thioester, carboxylic acid nucleophilic acyl substitution reduction thionyl fluoride mediated, amino acid peptide coupling protection and other aspects.Safety of tert-Butyl trichloroacetimidate
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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics